Browse Erie County Businesses for Sale in Buffalo, NY

Discover the best Erie County businesses for sale on DealStream, the premier online marketplace for buying and selling established businesses throughout Western New York. Our comprehensive Erie County NY business listings span restaurants, retail shops, manufacturing operations and service-based ventures in Buffalo, Amherst, Cheektowaga and beyond—easily filter by price, industry and revenue to pinpoint opportunities that match your investment goals. Start browsing now to connect directly with motivated sellers and take the next step toward owning a profitable business in Erie County.

All Matching Deals

Erie County, NY

This offering represents an exceptional opportunity to acquire a well-established, fully licensed childcare center with a strong reputation for safe, dependable, and developmentally focused care. Serving infants through school-age children, the center enjoys consistent enrollment and strong community...

$1,100,000
Cash Flow: $275,000
Details
Erie County, NY

Business is a highly reputable and profitable chiropractic clinic located in Williamsville, NY. Established in 1987, this long - established practice boasts a loyal, multi - generational patient base, efficient operations, and consistent financial performance — making it an exceptional opportunity!...

$800,000
Cash Flow: $550,000
Details
Erie County, NY

Seller is retiring and looking for a new owner. Longstanding pizzeria and family dining restaurant available with the real estate included. This well-known local favorite has served the community for many years and enjoys a loyal customer base with steady dine-in and takeout sales. The property is well-maintained,...

$350,000
Cash Flow: $100,000
Details
Electrical  Panel  Manufacturer
West Seneca, NY

Thirty-Five year old company is an industry leader in custom control panel design, manufacturing, and installation. Their experience and expertise as a control panel and process skid manufacturer includes almost 30 years of research and development. They supply customers who need pneumatic control...

$1,750,000
Details
Food Manufacturing Business for Sale
Erie County, NY

Fully equipped, industrial kitchen designed to produce high-quality Colombian arepas (pronounced ah-ray-pa) or pierogis. This sale includes recipes and assistance with this business. This is a turn-key operation, ready to go. This kitchen can be adapted to many cuisines. Here are just some of the...

$150,000
Details
East Amherst, NY

Listing #1540 – East Amherst, New York – Fee for service general dental practice located in a high-traffic location in a beautiful building. The office has five operatories of new equipment with room for expansion. It is also fully digital, including a 3D digital pan, and is fully equipped for implant...

On Request
Details
Buffalo, NY

Listing #4250 - Buffalo, New York – Very busy general dental practice located in a great suburb in the south towns of Buffalo. The practice collects over $1.3M and nets close to $600,000 with over 3,000 active patients and high new patient flow. The office is newly built with eight operatories of...

On Request
Details
Buffalo, NY

General dental practice located in a high traffic commercial location in a north towns suburb of Buffalo. The practice collects over $2.5M and sees approx. 75 new patients per month. The office has eight operatories with newer equipment and is fully digital with CAD/CAM scanning and milling. The...

On Request
Details
Amherst, NY

Listing #4006 – Amherst, New York – High revenue general dental practice located in the beautiful Buffalo suburb of Amherst, NY. The practice collects over $1.4M annually with low overhead and only participates with the higher paying PPOs. The 2,500 SF office has six well equipped operatories with room...

On Request
Details
Hamburg, NY

Listing #7540 – Hamburg, New York – Well established general dental practice available in the Buffalo south towns suburb of Hamburg. The office has is very nice with three well equipped operatories of newer equipment and digital x-ray including a digital pan and also the possibility of expansion. ...

On Request
Details
Buffalo, NY

Listing #7841 – Buffalo, New York – Well established general dental practice for sale in a Northtown Buffalo suburb with a high traffic location. The practice collects over $450,000 on a very part-time basis and could increase revenue with the addition of insurance participation. This beautifully decorated...

On Request
Details
Amherst, NY

Listing #2824 – Amherst, New York – Well established underutilized part-time general dental practice available in the Buffalo suburb of Amherst, NY. The practice is only open three days per week and is collecting approx. $180,000 with two equipped operatories and room for expansion. The practice has...

On Request
Details
Williamsville, NY

Listing #1214 – Williamsville, New York – General dental practice collecting $900,000 and netting $500,000! The practice is in a high-traffic location in a very nice suburb of Buffalo. This office has four fully equipped operatories with Adec equipment and digital x-ray including a digital pan. The...

On Request
Details
Buffalo, NY

WNY PODIATRY PRACTICE AVAILABLE • It is an outstanding, long established, well known, profitable, dynamic, fully equipped and staffed, including an EMR system. • Its suburban Buffalo, NY professional office is visible, accessible, with ample adjacent parking and is available to lease or could easily...

$369,000
Details
Buffalo, NY

NEW Turnkey Shopify Startup Website Business. The website comes programmed with products and suppliers to drop ship the products for you. No programming skills or experience is required to profit from this highly lucrative industry.There is no inventory to carry and nothing to ship. You can own and...

$799
Details
Hamburg, NY

HAMBURG, NY PRACTICE FOR SALE: Established successful 'cash' practice collecting $467,940.00. Net cash flow [after add backs] $221,878.00. 270 new patients / 2,045 total visits. This is a low overhead - low stress - enjoyable practice. Exceptionally equipped. All management systems in place [total 'turn-key']....

On Request
Details
Buffalo, NY

OVERVIEW The client now services international trucking transportation to and from Western New York and the Port of New York/New Jersey. Our services include full containers as well as less-than-container shipments, export QC inspection for letters of credit, claims, and fumigation service. Buffalo...

On Request
Details
Mobile Catering - Priced To Sell
Erie County, NY

PRICED TO SELL.... Unique business opportunity. The company is based upon a unique concept in the mobile catering business. The business focuses on outdoor markets, industrial estates, festivals, and so forth, with no real competition. This business focuses on weddings (which is about 80% of our revenue),...

$46,500
Details
Unique Consulting & Dispatching Company for Sale
Erie County, NY

LISTING ID # 34635 This rather unique trucking consultants & dispatching company is now available in New York. They offer a niche service which is to help create trucking companies for individuals & investors as well as dispatch their loads and run their day to day operations, plus much more. This...

$600,000
Cash Flow: $220,000
Details

Tips for Buying A Business In Erie County, NY

Do Your Due Diligence

Before making any offer, conduct thorough due diligence on the business you're interested in purchasing. In Erie County, NY, it's essential to review financial statements, tax returns, and legal documents from the past few years. Talk to the current owner, employees, and even customers if possible. Examine the reputation of the business in local communities such as Buffalo, Amherst, or Cheektowaga, as regional reputation can significantly affect long-term success.

Understand Local Market Dynamics

Erie County has a unique economic landscape, shaped by its history, demographics, and proximity to Canada. Analyze the local competition, supply chain environment, and consumer trends specific to Western New York. Network with local business groups and the Erie County Industrial Development Agency for insights. These local nuances will help you identify growth opportunities and potential risks that outsiders often overlook.

Secure The Right Advisors

Work with experienced local professionals, including a qualified business broker, attorney, and accountant who understand Erie County regulations and business climate. Their connections with local lenders, government offices, and industry experts can simplify the buying process. Rely on their expertise to help you navigate zoning codes, licensing requirements, and tax incentives that may be available in the region for certain types of businesses.