Discover Profitable Businesses for Sale in Port St. Lucie, Florida

Discover Port Saint Lucie businesses for sale on DealStream, your go-to Florida business marketplace. Our curated listings showcase turnkey restaurants, retail shops, service firms and more in Port St. Lucie’s booming market. Whether you’re a seasoned investor or an aspiring entrepreneur, explore profitable Florida business opportunities in one of South Florida’s fastest-growing cities. Start browsing today to find your ideal business investment in Port Saint Lucie and launch your next venture with confidence.

All Matching Deals

High-End Relocation Business – 95% Repeat Clients
Port Saint Lucie, FL

This is a rare opportunity to acquire a well-established, highly reputable business specializing in global vehicle and specialty equipment relocation. The company has built a strong reputation for white-glove service, reliability, and long-term client retention. It handles a wide range of relocations—including...

$1,249,000
Cash Flow: $277,171
Details
Port Saint Lucie, FL

This is a rare and strategically positioned opportunity to acquire a multi-unit, multi-revenue stream franchise operation within the highly stable and recession-resistant tax and financial services industry. The offering includes two company-owned storefronts, both located in high-traffic retail...

$978,380
Cash Flow: $227,352
Details
Popular Artisan Ice Cream Shop. High Traffic Area.
Port Saint Lucie, FL

PREMIUM ARTISAN ICE CREAM & SPECIALTY DESSERT CONCEPT – Turnkey, Branded, and Scalable. This is a rare opportunity to acquire a highly differentiated, brand-forward artisan ice cream and specialty dessert business that has successfully positioned itself at the intersection of customization, experience,...

$125,000
Details
Port Saint Lucie, FL

For $199,000, acquire a single, high-visibility retail franchise location in a proven tax and financial services model. This turnkey opportunity includes seasonal tax preparation along with year-round bookkeeping, payroll, and advisory services, ensuring consistent cash flow through all seasons. As...

$199,000
Cash Flow: $78,655
Details
Port Saint Lucie, FL

This is an ideal opportunity for an established restaurant looking to expand with a second location. The pizzeria, spanning 1,082 SF, boasts a fully equipped kitchen and top-of-the-line equipment, including a Toast point of sale system with 2 registers, 2 kitchen monitors, printers, and more. With 6...

$115,000
Cash Flow: $56,922
Details
Port Saint Lucie, FL

This company has been established for over 15 years, with many long-standing accounts and the ability to add many more. This is a full service landscaping company, offering design & installation, maintenance, tree trimming etc. There are employees in place, including a foremen, ready to make this a...

$115,000
Cash Flow: $68,459
Details
Chifles Chips Route, St. Lucie County, FL
Port Saint Lucie, FL

Chifles Plantain Chips Route for sale in the St Lucie & Martin Counties, Florida region for $125,000! Currently grossing an estimated $530,364 per year in sales and nets an estimated $119,435! Distributorship and territory are purchased through independent distributor and contracted through Chifles....

$125,000
Cash Flow: $119,435
Details
Wildlife and Pest Control Service Business
Port Saint Lucie, FL

Established in 2016 this Sarasota, Florida based wildlife control service business is being offered for an asking price of $120,000. The business is a family-owned company with a quality reputation earned over the years. The seller has had an injury and health issues unrelated to the business, now ready...

$120,000
Cash Flow: $30,275
Details
Port Saint Lucie, FL

Is this the best pizza outside of New York? This established and profitable neighborhood pizzeria can be yours. Featuring NY style pizza and authentic Italian dishes plus wings, cheesesteaks, gyros pasta and so much more. This business is corporately owned, the owner has no day to day operational involvement....

$375,000
Cash Flow: $180,820
Details
Port Saint Lucie, FL

LOCATION Company: Allstate City/State: St Lucie County, Florida County: St. Lucie Zip Code: 34952 Location Available: Yes Rent/Lease Terms: With signed NDA Rent/Lease Rate: With signed NDA F&E Available: Yes Years in business: 14 Years Location Photos: With signed NDA Current Agency...

$1,500,000
Details
Port Saint Lucie, FL

12 yrs in business-Owner is motivated/ has other interests and will train for 30 days(20 business days).Price Includes truck, some parts inventory and other tools of the trade. Must seek immediate manufacturer training and certification from Generac. This business is home based and relocatable with...

$150,000
Cash Flow: $65,000
Details
Port St. Lucie, Fl, Practice for Sale
Port Saint Lucie, FL

35 year successful chiropractic wellness practice collecting $500,904.00. 8,164 total visits. Open 3 full/2 half days weekly. Exceptionally staffed and equipped. Ideal location - just one block from HCA Medical Center & many medical offices. One block off US 1 for easy access to the practice. 10k new...

On Request
Details
Port Saint Lucie, FL

Custom Retail Furniture Manufacturer

$800,000
Details

Tips for Buying A Business In Port Saint Lucie, FL

Understand the Local Market

Before you make any offers, take time to research the Port Saint Lucie business landscape. The city is growing rapidly, but its economy is highly influenced by local demand, seasonal trends, and population shifts. Study the key industries in the area—such as healthcare, hospitality, and construction—and determine which types of businesses have long-term viability. Speak with other local entrepreneurs, visit the Chamber of Commerce, and use online resources to identify patterns and potential challenges unique to the region.

Conduct Thorough Due Diligence

No matter how promising a business looks on paper, due diligence is critical. Review financial records for at least the past three years, including tax returns, profit and loss statements, and balance sheets. Don't forget to inspect lease agreements, outstanding debts, and legal or regulatory issues that may affect the operation. In Port Saint Lucie, certain businesses may require specific permits or face zoning restrictions, so verify that the business complies with all city and state regulations before proceeding.

Evaluate Growth Opportunities

After you’ve verified the financial health and operational soundness of the business, look for avenues of growth specific to Port Saint Lucie. The city’s expanding population brings increasing demand for many goods and services. Consider businesses with potential for expansion, such as those that could benefit from tourism, the influx of retirees, or new housing developments. Discuss your ideas with local advisors and factor in the ability to implement new marketing strategies, expand product offerings, or establish new locations as part of your decision-making process.