Mississippi Businesses for Sale: Top Opportunities for Entrepreneurs
Discover the largest selection of Mississippi businesses for sale on DealStream. From restaurants and retail shops to service-based enterprises, our Mississippi business listings feature verified opportunities in Jackson, Gulfport, Biloxi and beyond. Whether you’re an experienced entrepreneur or buying your first business in Mississippi, you’ll find detailed financials, owner-financing options and expert broker support to guide you every step of the way. Browse now to buy a business in Mississippi and secure your next profitable investment in the Magnolia State!
Showcased Deals
Turnkey Well Built Molecular Lab in MS
Turnkey well-built molecular laboratory in Novitas (Mississippi). This CLIA Certified 3300 sq ft laboratory is currently built out for molecular testing utilizing the Biofire Film Array Torch System, QuantStudio 5k, and the KingFisher Flex for extraction. In addition to the key pieces of instrumentation,...
Established Ophthalmology Practice
This well-established ophthalmology clinic has been serving the community for over four decades, offering comprehensive eye care, routine exams, glaucoma treatments, and an in-house optical shop. With a strong patient base of 25,000+, steady referral streams, and significant growth potential in cataract...
All Matching Deals
Turnkey Well Built Molecular Lab in MS
Turnkey well-built molecular laboratory in Novitas (Mississippi). This CLIA Certified 3300 sq ft laboratory is currently built out for molecular testing utilizing the Biofire Film Array Torch System, QuantStudio 5k, and the KingFisher Flex for extraction. In addition to the key pieces of instrumentation,...
Established Ophthalmology Practice
This well-established ophthalmology clinic has been serving the community for over four decades, offering comprehensive eye care, routine exams, glaucoma treatments, and an in-house optical shop. With a strong patient base of 25,000+, steady referral streams, and significant growth potential in cataract...
Medical Cultivation Operation in Mississippi
Broker presents this Medical Cultivation Operation For Sale in Mississippi. The company is renowned for its premium products, which makes it a preferred supplier for many dispensaries. It holds a significant market share in a rapidly growing medical market, with products distributed to a large number...
Growing Transportation Business in MS
Tremendous opportunity to acquire a growing transportation business. This highly regarded leading transportation business was founded by the current owner in 1997 and specializes in hauling a diversified portfolio of Construction Aggregates and O&G products. The company operates from a business-owned...
Flowers Bread Route, Waynesboro, MS
Flowers Bread Route distributorship for sale in the Waynesboro, Mississippi region for $154,000! Company related financing available with an estimated $74,000 down. In addition, a 10% cash reserve of the selling price will be required. This route is currently grossing an estimated $588,117 per year...
Non-Surgical Regenerative Pain Treatment Centers
Non-surgical regenerative clinics that provides medicine treatments for chronic pain caused by arthritis, injuries, or day-to-day, repetitive activities by treating damaged joints, muscles, tendons, ligaments, cartilage and connective tissue. Innovative treatments, which include Class IV deep tissue...
Truck Dealership, Rent-to-Own Class 8 in MS
This is a unique opportunity to acquire a fully operational Rent-to-Own Class 8 Truck Dealership with prime commercial real estate available separately. Strategically located along a major trucking corridor and adjacent to national truck stops. This high-visibility site is built to scale with infrastructure...
Premiere Pediatric Cardiology Practice For Sale
Pediatric Cardiology Practice Posed for Growth The founding physician established this practice to provide expert care in pediatric cardiology and has led it through significant growth over the past twelve years. The practice is built on core values: prioritizing patient care, ensuring needs are...
Halal Mediterranean Grocery Store Business-only
Sales are currently averaging $75,000 per month! Net profit is over $10,000 per month AFTER paying $8,000 in Payroll, rent, and all other expenses! Owner Operator can take home over $16,000 per month! Rent is $6,112 NNN plus CAM per month with 3 years remaining on the current lease! Rent increases...
Gas Station with Property in Vaiden, MS
Owner bought the store last year when it was an Exxon. Previously did $80,000 inside sales under Exxon, but sales declined when it went unbranded and Seller additionally had employee issues! Outside sales were previously 65,000 gallons as Exxon! Seller closed for two months for inside renovations!...
Medical Practice - Primary Care & Urgent Care
Well-established medical practice operating across three thriving locations: two Primary Care clinics and one Urgent Care center. The practice is staffed by a dedicated team of eleven full-time and part-time practitioners and also provides care to a local nursing home. With a strong patient base and...
Dry Gas Station with Property in Hickory Flat, MS
Key Financials: Dry Gas Station! County is dry and does not allow alcohol sales! Inside Sales are an average of $70,000 per month! Inside Sales in August 2025 were $73,000! Of that $73,000, Vape Sales were $13,500 at high margins! Outside Sales average 50,000 gallons per month with an average...
Liquor Store & Gas Station w/ Property in Jackson
Liquor Store Net Sales are $170,000 per month! Buyer can take advantage of the upcoming Holiday season sales! Gas station Inside sales are averaging $52,000 per month! Sales are increasing rapidly! ATM commission is $400 per month! Seller has recently taken full control of the gas station....
Portable Restroom & Septic Services - Mississippi
Asking Price: Inquire Revenue: $1,700,000+ Adjusted EBITDA: ~$500,000 Location: Mississippi A rare opportunity to acquire a well-established portable restroom rental and septic services provider with a strong reputation, recurring customer base, and high-quality assets. This turnkey operation...
Iconic Home & Garden Center - One Stop Retail
The Company maintains one of the South's largest inventories of gardening products while providing expert consultation services through certified and trained professionals. This combination of extensive product selection and knowledge-based service creates a unique competitive advantage in the market Business...
C-Store with Property in Gulfport, MS!!
Key Financials: Asking Price is only $899,000 plus inventory! Inside Sales are currently averaging $100,000 per month at a 35% margin! Sales for just September 2025 were $109,651! Sales for May this year were $119,000! June Sales were $108,000! Lottery Commission is $1,500 per month! Air...
Boutique Advertising and Marketing Agency in MS
This boutique advertising and marketing agency, based in Mississippi, has been operating for over 15 years. The company provides creative strategy, media planning and buying, and full-service campaign execution. It has earned a strong reputation for quality, integrity, and long-term client partnerships...
High Volume Gas Station with Property in Indianola
Inside Sales are averaging over $100,000 per month! Deli sales are an average of $43,000 of that $100,000 inside sales! Deli is generating a high 50% margin! Seller does NOT have Lottery, ATM, nor an Air Machine! Huge opportunity to add Lottery and generate significantly more income! Outside...
3 Brand New Truck Stop In Prime Locations For Sale
3 Brand New Truck Stop In Prime Locations For Sale In MS New to the market are 3 truck stops that are currently under construction and should be completed with in 1 month. The seller is offering each truck stop for $5,500,000 with a fuel contract attached from a major franchise. These 3 truck stops...
Brand New Build Truck Stop $3.8 MM For Sale
Brand New Build Truck Stop $3.8 MM For Sale In Olive Branch, MS Looking to add a truck stop to your portfolio? Look no more; this station is the one. Brand new build with no expense spared, this truck stop will have a 3,000-square-foot convenience store with two additional storefronts for rental...
15 Unbranded Gas Station Portfolio in MS
15 Unbranded Gas Station Portfolio in MS Store $1.4 Monthly Gas 645K Monthly Business and Property. One seller, 15 gas stations, with one gas station being built from the ground up brand new. This portfolio is with business and property and is being delivered with no fuel contract. If you're a jobber...
Profitable Childcare Business for Sale – Establish
This established childcare business has been providing exceptional care for over 22 years. Specializing in infants, toddlers, preschoolers, and after-school care, it has built a reputation for offering a safe, nurturing, and educational environment. With a loyal client base and a strong community presence,...
3 Brand New Truck Stop In Prime Locations For Sale
3 Brand New Truck Stop In Prime Locations For Sale In MS New to the market are three truck stops that are currently under construction and should be completed in one month. The seller is offering each truck stop $5,000,000 with a fuel contract attached from a major franchise. These 3 truck stops...
Pharmacies for Sale
Retail pharmacies for sale within well established supermarket location, with low overhead, favorable leases with good rebate history Buy both or individually. Sales of 1M dispensing 26,000 annually and sales of 2.5M dispensing 34,185 annually. Located in Pearl River county and Lamar county Mississippi.
Thriving Bakery and Cafe in Mississippi
LISTING ID # 36509 Thriving Bakery and Cafe on Major Roadway. This is a true gem. The business and property are both available for sale. The business has shown year over year growth and is located in a 4 lane highway. They currently serve lunch only. This is a spacious 3,600 sf facility with ample...
Tips for Buying A Business In Mississippi
Research the Local Market Thoroughly
Before purchasing a business in Mississippi, it's vital to conduct thorough research on the local market. Understand the economic environment of the state and the specific region where the business operates. Mississippi has unique industry clusters, such as agriculture, manufacturing, and tourism, which each have their own challenges and opportunities. Analyze trends, customer demographics, and competitors. Reach out to the local Chamber of Commerce or business development groups to gather data and insights that can help you assess the business’s growth potential.
Perform Rigorous Due Diligence
Due diligence is a critical step in making a wise investment. Examine the financial health of the business by reviewing tax returns, balance sheets, income statements, and cash flow reports from the past several years. Investigate any outstanding debts, legal liabilities, or pending litigation. In Mississippi, be mindful of state-specific issues like property taxes, business licenses, and compliance with state labor laws. Consult with a CPA, attorney, or business broker familiar with transactions in Mississippi to ensure there are no hidden surprises.
Build Local Relationships
Building strong relationships in the community can significantly boost your chances of success. Mississippi is known for its close-knit communities, so take time to connect with local vendors, customers, and other business owners. This network can be invaluable for gaining insights, earning referrals, and navigating regulatory matters. Participate in local events and join business associations to become an active member of the business community, which can lead to new opportunities and a smoother transition after the purchase.
Browse Other Categories In Mississippi
- Auto Repair
- Companies
- Construction
- Convenience Stores
- Franchises
- FSBO Businesses
- Gas Stations
- Healthcare
- Investment Opportunities
- Manufacturing
- Medical Practices
- Middle Market Businesses
- Owner Financed Businesses
- Pharmacies
- Restaurants
- Retail Stores
- Small Businesses
- Transportation
- Wholesale Businesses
Browse By Locations In Mississippi
- Harrison County, MS
- Hinds County, MS
- De Soto County, MS
- Sunflower County, MS
- Pike County, MS
- Rankin County, MS
- Jackson County, MS
- Simpson County, MS
- Lauderdale County, MS
- Lafayette County, MS
- Gulfport, MS
- Jackson, MS
- Olive Branch, MS
- Ocean Springs, MS
- McComb, MS
- Laurel, MS
- Meridian, MS
- Brandon, MS
- Southaven, MS
- Oxford, MS