Buy Businesses for Sale in Harrison County, Mississippi

Explore Harrison County businesses for sale on DealStream—your go-to marketplace for profitable Mississippi business listings in Gulfport, Biloxi and the surrounding Gulf Coast. From turnkey restaurants and retail shops to service providers and light manufacturing, our up-to-date opportunities include detailed financials, owner transition support and direct seller contacts. Start your search today to unlock the best Harrison County business opportunities and take the next step toward entrepreneurship in Mississippi.

All Matching Deals

Established Ophthalmology Practice
Gulfport, MS

This well-established ophthalmology clinic has been serving the community for over four decades, offering comprehensive eye care, routine exams, glaucoma treatments, and an in-house optical shop. With a strong patient base of 25,000+, steady referral streams, and significant growth potential in cataract...

$775,000
Cash Flow: $344,447
Details
C-Store with Property in Gulfport, MS!!
Gulfport, MS

Key Financials: Asking Price is only $899,000 plus inventory! Inside Sales are currently averaging $100,000 per month at a 35% margin! Sales for just September 2025 were $109,651! Sales for May this year were $119,000! June Sales were $108,000! Lottery Commission is $1,500 per month! Air...

$899,000
Cash Flow: $198,000
Details
3 Brand New Truck Stop In Prime Locations For Sale
Gulfport, MS

3 Brand New Truck Stop In Prime Locations For Sale In MS New to the market are 3 truck stops that are currently under construction and should be completed with in 1 month. The seller is offering each truck stop for $5,500,000 with a fuel contract attached from a major franchise. These 3 truck stops...

$5,500,000
Details
Packing, Shipping, Printing & Business Services Center located on the Missis
Gulfport, MS

This is an excellent opportunity to acquire an existing packing and shipping store that does so much more. We provide services to the community such as copying, printing, binding, lamination, notary service, shredding, personal mailboxes (in store and virtual), faxing, passport photos, gifts, gift wrapping,...

$140,000
Cash Flow: $30,000
Details
Gulf Coast Auto Repair & Used Car Dealer
Gulfport, MS

This BBB certified Auto Repair shop and used car business for sale is located on the Mississippi Gulf Coast and provides services for both business and residential customers. Having been owned and operated by the same family for almost 10 years, the company is well established and has a fully trained...

$170,000
Cash Flow: $81,369
Details
Gulfport, MS

PowerHouse Unbranded Gas Station $250K Inside 160 outside $980 Net Profit 1 Acre Property New and off the market gas station that was built brand new in 2011. This gas station will not disappoint anyone looking for a good return on your investment, the cape rate is at a 17 % WOW. Everything new...

$5,500,000
Details
Profitable MS. Gulf Coast Liquor and Wine Store
Gulfport, MS

This profitable business was established in 2021 and is located in the Mississippi Gulf Coast. This business experiences a high rate of customer satisfaction with a loyal customer following. The owner has stocked the store with a full line of liquor and a wide range of wines, including top labels.

$299,000
Cash Flow: $117,000
Details
Liquor Store for Sale in Harrison County, MS
Harrison County, MS

Listing ID # 21029 Perfect liquor store in great location. Established for five years. Located next to a bar, and at the entrance of a mobile home park. Only liquor store in 6-mile radius. Lots of room for expansion, and much money to be made.

$275,000
Cash Flow: $36,112
Details

Tips for Buying A Business In Harrison County, MS

Understand the Local Market Dynamics

Before pursuing any business purchase in Harrison County, MS, it’s vital to immerse yourself in the local market. Spend time researching the economic climate, key industries, and growth trends in the area. Pay close attention to the tourism sector, the impact of Gulf Coast commerce, and developments in surrounding cities such as Biloxi and Gulfport. This foundational knowledge will help you assess which types of businesses have lasting demand and identify any seasonal or cyclical fluctuations that might affect revenue.

Conduct Thorough Due Diligence

When evaluating a target business, don’t just rely on surface-level information. Scrutinize financial statements, tax returns, and legal documentation for the past several years. Visit the physical location unannounced and observe operations; speak discreetly with employees and, if possible, regular customers. A thorough due diligence process will help you uncover hidden liabilities—such as outstanding debts, legal disputes, or regulatory compliance issues—that could impact your investment after closing.

Assess Community Fit and Reputation

Harrison County, like many coastal Mississippi communities, values relationships and word-of-mouth reputation. Evaluate how the business is perceived locally by talking to neighboring business owners and reviewing customer feedback online. A business with deep community ties and a positive reputation provides a strong foundation for future growth. Conversely, a poor local reputation can be difficult and costly to overcome, even with extensive rebranding or management changes. Prioritize businesses that already have established trust within the community.