Franchises for Sale in Missouri: Top Opportunities 2025
Looking to buy a franchise in Missouri? Explore hundreds of Missouri franchises for sale on DealStream, the premier online marketplace for franchise business opportunities. From food and beverage to fitness and retail, our up-to-date listings cover St. Louis, Kansas City, Springfield and beyond—complete with asking prices, revenue data and financing options. Start your search today and find the perfect Missouri franchise opportunity to match your budget and goals!
All Matching Deals
Profitable Home Care Provider – Central Missouri
This Founder Operated home care company has built an award-winning reputation for compassion and professionalism. Essential services are centered around personal and companion care, enabling older adults/veterans to age in place with independence, dignity, and grace. The retiring Founders seek to...
Well Established Staffing Agency in Rolla
Steady business that thrives regardless if the economy is up or down. This staffing agency provides temporary and long-term employees to a local economy of around 5,500 businesses and 60,000 employees. Manufacturing, logistics, and construction are big here. All very in-demand, essential industries....
Established Chem-Dry Franchise for Sale
Own a profitable, well-known cleaning franchise backed by one of the most trusted names in the industry. Chem-Dry is a global leader in carpet and upholstery cleaning services. This franchise operates in a recession-resistant industry where cleaning services remain in constant demand. Ownership is flexible,...
Absentee-owned Profitable Kick Boxing Gym
Absentee-owned kick boxing gym franchise for sale in St. Peters Missouri! Only kick boxing gym in the area open 24x7, 365 days a year. Gym offers trainer-led, self-guided and virtual experiences. Current owner only spends 2-3 hours a week monitoring business. Gym is fully staffed and was refurbished...
Children's Party Entertainment Center
This children’s party entertainment center has been a one-stop shop for some family friendly fun for almost 2 decades. With multiple awesome locations and a lengthy track record, this could be your chance to purchase a great business that offers inflatables, great parties and events for children.
Reduced / Established Staffing Agency - Rolla, MO
Reduced asking price! Established staffing and recruiting agency in Rolla, MO. The office provides an opportunity to acquire a turn-key business and continue to grow on an excellent book of business. Fully furnished with a trained staff and training provided for the new owner. This existing agency...
Profitable Mobility Franchise for Sale
This profitable mobility solutions business offers a diverse range of products, including scooters, power walkers, stair lifts, hospital beds, and more. Customers can also rent mobility equipment for short-term needs, making it a go-to provider for both temporary and long-term solutions. As part of...
Insulation Business - Comfort and Cash Flow
This profitable insulation services franchise has an established reputation for quality, professionalism, and customer satisfaction. The company provides a wide range of energy efficiency solutions, including spray foam, blown-in, batt insulation, and attic/air sealing, serving both residential and...
Baked Goods Niche with Management in Place
This acquisition opportunity represents multiple franchise locations in the baked goods niche, strategically positioned in a high-growth region within the US. One of the locations is the top performing franchise location in the metropolitan area that it is located within, and one of the top performing...
Profitable Duct Cleaning Co
Looking for a business that blows away the competition? This well-established, confidentially listed franchise specializes in air duct cleaning and HVAC restoration services, offering a proven model with strong cash flow, recurring revenue, and a growing customer base. Operating under a nationally...
Very Busy Grocery Store
Well-established grocery store with a licensed gaming machines. Located in a high-traffic area with steady customer base. Features: Fully stocked grocery inventory Operating gaming machines (licensed) Walk-in coolers & freezers POS system included Low overhead, strong daily sales Ample parking...
Established Grocery Store - Very Busy
Well-established grocery store with a licensed gaming machines. Located in a high-traffic area with steady customer base. Features: Fully stocked grocery inventory Operating gaming machines (licensed) Walk-in coolers & freezers POS system included Low overhead, strong daily sales Ample parking...
Custom Window Treatment Company
Custom Window Treatments - Showroom on Wheels Custom window treatment company specializing in providing high-quality window coverings, including blinds, shades, shutters, draperies and exterior shades. Offering options for automation and motorization. There is a proprietary line allowing clients...
Mid-America Franchise Landscape Services Business
A compelling acquisition opportunity with strong value, operational stability, and recurring customer demand. Modern equipment, a great staff and long-term customers relationships are all here. Major competitive advantages: Consistent Profitability – Stable revenues and predictable profits from...
Profitable Print Shop -Rapidly growing Ozarks area
Print shop in a fast-growing area does custom signs and graphics, apparel, and more. All assets are free and clear. In business since 2009. Diversified, loyal customer base including both B2B and B2C. Much room for new growth as businesses are booming and expanding in the area. Owner is getting ready...
Established Sylvan Learning Franchise For Sale
This turnkey opportunity is for Sylvan Learning of Springfield, MO — a profitable, nationally recognized K–12 tutoring and test-prep franchise with a 30+ year community presence. Located in south Springfield near Walmart Super Center South, the 1,960 sq ft leased facility serves approximately 70 active...
Cecil Whittaker's for Sale in Outstanding Location
Pizza franchise that has been around for over a decade with a successful history in this location. This location’s majority of sales are take-out and therefore they were barely affected by the pandemic. With no competition in the immediate surrounding area, this business has room to grow.
Turnkey Drywall Franchise with Prime St. Louis Territories
Perfect opportunity for a Drywall Professional looking to become an owner-operator and experience unlimited income potential, flexible hours, in a project-based environment. Customers pay for most services check or credit card the day of completion. This Semi-Absentee owner PatchMaster franchisee holds...
Fitness Franchise 3-locations in the Midwest
This Multi-unit fitness franchise is based in the Midwest. Seller has some of the top performing stores across the entire country, including the #1 store. These gyms are in 2 different neighboring states. Sellers are looking to pursue some new opportunities in another state which has motivated them...
Lighting Business for Sale
Current owner has 2 locations but wants to focus on just one. Current business generates leads via website and referrals. Customer list included. Business is debt free. Great opportunity to pick up and build this location.
Food and Beverage - Deli
MANAGEMENT IN PLACE - GREAT LOCATION - This popular, thriving and profitable deli located in Jefferson County, Missouri is located in a highly visible location and offers a drive through window as well as indoor seating. Highly qualified manager in place. The classic Italian menu offers sandwiches,...
Compassionate Senior Services and Care Business
Booming industry for elderly care clients. This business is a franchise opportunity as a stand-alone business or possibly an add-on to your already existing business. The current owner would be available to stay on but wants to step out of day-to-day business operations.
Imo's Pizza Franchise w/Recent Price Reduction
Profitable Imo’s pizza franchise for sale in the St. Louis Region. Beautifully maintained restaurant is fully staffed and ready for new ownership. The restaurant has it all dine-in, drive-thru and delivery. Business has consistently produced six figure income for owner. This franchise presents an excellent...
Franchise Restaurant for Sale with Absentee Owner
Recent Price Reduction! Key management has been in place for over a decade. Seller has a full-time career and wants to focus more on that. Many nearby competitors have shut down or moved over the past few years, giving the business a positive outlook for revenue growth in the area. Seller has a...
Tips for Buying A Business
Understand Your Goals and Criteria
Before you begin your search, clearly define what you want to achieve by buying a business. Consider your interests, skills, lifestyle requirements, and financial capacity. Are you looking for a hands-on role in a local business or a more passive investment? Make a list of key criteria—such as industry preferences, location, size, and profitability—so you can quickly rule out businesses that don’t align with your vision.
Conduct Thorough Due Diligence
Once you find a business that interests you, devote significant effort to the due diligence process. Carefully review financial statements, operational records, employee contracts, leases, and customer agreements. Look for red flags such as inconsistent revenues, pending legal issues, or outdated equipment. Consider hiring accountants, lawyers, and other professionals to help you validate the information and uncover any hidden risks.
Build Strong Relationships
The success of the transaction often depends on the relationships you establish—with the seller, key employees, and clients. Open and respectful communication with the seller can foster trust and facilitate a smoother negotiation and transition period. After the purchase, retaining and motivating key staff and maintaining strong customer relationships will be crucial for ongoing success and growth.
Browse By Locations In Missouri
- Saint Louis County, MO
- City of Saint Louis, MO
- Saint Charles County, MO
- Jackson County, MO
- Franklin County, MO
- Phelps County, MO
- Jefferson County, MO
- Cape Girardeau County, MO
- Greene County, MO
- Boone County, MO
- St Louis, MO
- Kansas City, MO
- Saint Charles, MO
- Clayton, MO
- O'Fallon, MO
- Rolla, MO
- Columbia, MO
- Lebanon, MO
- Cape Girardeau, MO
- Springfield, MO