Pharmacies & Drug Stores for Sale in Pennsylvania

Looking to buy a pharmacy in Pennsylvania? Explore DealStream’s premier marketplace for pharmacies and drug stores for sale across PA, from Philadelphia and Pittsburgh to Harrisburg and beyond. Whether you’re a licensed pharmacist ready to step into ownership or an investor seeking high-margin retail pharmacy opportunities, our up-to-date listings feature turnkey operations, transparent financials, owner financing options, and prime locations. Start browsing now to compare prices, review detailed profiles, and connect directly with sellers—your next successful Pennsylvania pharmacy acquisition is just a click away!

All Matching Deals

Pennsylvania

Busy and profitable retail pharmacy in Central Pennsylvania. This pharmacy has been in business for over 20 years and has annual sales of $7.5 Million and fills over 107,000 prescriptions per year. There is approximately $350,000 in prescription inventory and $25,000 in front end inventory. LTC is...

$1,000,000
Details
Pennsylvania

Pharmacy located in the North East. Licenses in 51 states.Urac and Vipps accredited. Optum mail order agreement . Medicare PTAN.

On Request
Details
LTC-Only Pharmacy in Lackawanna County, PA
Lackawanna County, PA

This LTC-only pharmacy is located in Lackawanna County, Pennsylvania, serving the greater Scranton, PA market. The pharmacy has operated from its current location for more than 12 years and has built a strong reputation among long-term care providers throughout the region. The opportunity is well-suited...

On Request
Details
Thriving Retail Pharmacy for Sale in Western PA
Pennsylvania

Seize the opportunity to own a well-established traditional retail pharmacy that has been a trusted fixture in the community for decades. Filling over 1,600 prescriptions weekly and generating over $6.3 million in annual revenue, this pharmacy combines steady profitability with a loyal customer base....

On Request
Details
Established Retail Pharmacy in Philadelphia
Philadelphia, PA

Established Retail Pharmacy for Sale – Prime Western Philadelphia Location Situated at a highly visible corner directly across from a busy hospital and medical center, this well-established retail pharmacy has been serving the community for four years, operating six days a week. Prime Location: High-traffic...

On Request
Details
Independent Pharmacy for Sale in Cumberland County
Cumberland County, PA

Cumberland County – Central Pennsylvania Take advantage of this rare opportunity to acquire a well-established independent pharmacy in the heart of Central Pennsylvania. Owned and operated by the same pharmacist for over 36 years, this pharmacy is now available due to the owner’s planned retirement....

On Request
Details
Retail Pharmacy – Philadelphia, PA
Philadelphia, PA

Retail Pharmacy – Philadelphia, PA A well-established, fully licensed, and compliant retail pharmacy in a strong neighborhood setting. With stable operation, low rent, and room for growth, this is an excellent opportunity for a pharmacist-owner or independent operator seeking to expand in the Philadelphia...

On Request
Details
Potter County, PA

Located in the heart of the Pennsylvania Wilds, this well-established independent pharmacy enjoys a strong reputation and loyal customer base. Positioned in a prime location with excellent visibility, the store generates approximately $1.3 million in annual pharmacy revenue and fills 28,000 prescriptions...

On Request
Details
Closed-Door Pharmacy Holds State Contracts
Pennsylvania

This closed-door pharmacy serves long-term nursing facilities, acute care spaces, assisted living and group homes, as well as schools, camps, hospitals and hospice. Skilled in management services for government offices, company also performs seasonal contracting and specialty pharma work. Business...

$3,210,000
Cash Flow: $321,000
Details
For Sale: Established Pharmacy in Northeast Philad
Philadelphia, PA

Asset Sale Description Asset Sale: Established Pharmacy in Northeast Philadelphia Don't miss this opportunity to acquire a trusted pharmacy in operation since 2012. Ideal for entrepreneurs or pharmacists ready to hit the ground running with an established customer base and extensive support. Asset...

On Request
Details

Tips for Buying Pharmacies and Drug Stores In Pennsylvania

Understand State and Federal Regulatory Requirements

Pennsylvania has its own unique set of requirements for pharmacy ownership, in addition to federal regulations. Before purchasing a pharmacy or drug store, familiarize yourself with the Pennsylvania State Board of Pharmacy rules, including licensing, staffing, security, and record-keeping standards. Confirm that the business is in full compliance before acquiring it. Also, understand federal laws such as HIPAA, DEA regulations for controlled substances, and Medicare/Medicaid participation rules. Consulting with a healthcare attorney or pharmacy compliance expert can help you avoid costly legal pitfalls.

Evaluate Location, Competition, and Patient Demographics

The success of a pharmacy is largely determined by its location and the local market dynamics. Analyze the store’s proximity to residential areas, physician offices, hospitals, and other healthcare businesses. Research the demographic profile of the surrounding community, focusing on age, insurance coverage, and population trends, as these factors directly impact prescription volume and product sales. Study the presence and strength of competitors, including chain pharmacies and discount retailers. Understanding these variables will help you determine the growth potential and whether the asking price is justified.

Scrutinize Financial Performance and Third-Party Contracts

A thorough financial review is crucial. Examine at least three years of tax returns, profit-and-loss statements, and prescription volume reports to assess revenue, profitability, and seasonal trends. Closely review reimbursement rates with pharmacy benefit managers (PBMs), wholesaler agreements, insurance contracts, and Medicare/Medicaid participation, as these directly affect your bottom line. Look for any outstanding liabilities, such as chargebacks or recoupments, that may transfer to you as the new owner. Engaging an accountant with pharmacy experience can provide valuable insights and help you spot any red flags before making your offer.