Texas Pharmacies & Drug Stores for Sale | Browse Listings Today

Pharmacies and Drug Stores For Sale in Texas Discover a curated selection of pharmacies and drug stores for sale across Texas, from high-traffic independent pharmacies in Houston and Dallas–Fort Worth to community-focused drug stores in Austin and San Antonio. Our DealStream listings provide detailed financials, turnkey operations and dedicated seller support to help entrepreneurs and investors secure the ideal acquisition. Whether you’re a first-time buyer or seasoned owner, browse now to find your next Texas pharmacy investment and accelerate your business growth.

All Matching Deals

Texas Specialty Pharmacy Operation - two locations
Texas

Well run pharmacies with a full staff (including pharmacists, technicians, and customer service reps) who would stay on post transaction. Pharmacies are currently absentee run, making this the perfect opportunity for a buyer looking to add a pharmacy to their portfolio. Seller is looking for a buyer...

$5,850,000
Cash Flow: $2,372,429
Details
Highly Profitable Texas Pharmacy
Texas

High volume and very profitable pharmacy specializing in specific disease states. This pharmacy has been in business for over five years with continued growth. All major PBM contracts in place through PSAO. Fully staffed and easily operated by an absentee owner. Direct contracts with many pharma manufactures....

$12,950,000
Cash Flow: $4,892,969
Details
Texas Pharmacy
Texas

This pharmacy is fully staffed and easily operated by an absentee owner. Direct contracts with many pharma manufactures. Established Prior-Authorization P&P. Pharma voucher program contracts in place. Annual Sales $12,656,546.00 Gross Profit $1,239,635.60 EBITDA $559,528.00 Annual Rx Count 29081 Asking...

$1,680,000
Cash Flow: $559,528
Details
Texas Retail Pharmacy
Texas

Great opportunity to acquire a long standing pharmacy with clean licenses and contracts. The pharmacy must be moved as the lease cannot be renewed. Licenses, contracts, FF&E and files are included. The inventory value will be taken on the day of transfer but is currently estimated to be 60k. Annual...

$150,000
Cash Flow: $46,272
Details
Texas Pharmacy in DFW area
Dallas, TX

Great opportunity to purchase clean licenses, DEA Registration with clean contracts. Long standing pharmacy within the DFW vicinity. Pharmacy is well known in the community and has a great reputation. Sellers are looking to retire. Annual Sales $1,132,533.67 Gross Profit $309,515.42 EBITDA $26,649.00 Annual...

$200,000
Cash Flow: $26,649
Details
Established Texas Gulf Coast Pharmacy
Texas

Highly Profitable Texas Pharmacy! Location: Southeast Texas near Gulf coast Sales: $3,700,000 Volume: 42,500 scripts/yr EBITDA: $270,000 Inventory: $150,000 Rent: $1,300/month Reason for Selling: Retirement Asking Price: $597K plus inventory Financial Performance: With annual sales of $3.7...

$597,000
Cash Flow: $270,000
Details
Texas

Profitable independent retail pharmacy in South Texas. Annual sales of $2.1 Million and filling over 3,000 prescriptions per month with an estimated inventory of $190,000.

On Request
Cash Flow: $185,286
Details
Established North TX Pharmacy - Price Reduction
Texas

Price Reduced! - Established Profitable Texas Pharmacy with Real Estate Location: Between 30 and 60 minute drive northwest of of Fort Worth Sales: $2,800,000 Volume: 48,000 scripts (190/day) Gross Profit: $580,000 Seller's Discretionary Earnings (SDE): $369,000 Inventory: $200,000 Real Estate:...

$200,000
Cash Flow: $120,000
Details
Houston, TX Area Retail Pharmacy
Houston, TX

Are you ready to step into the thriving Texas pharmacy market? We present a rare and lucrative opportunity to acquire Texas retail pharmacy with State Board of Pharmacy licenses, complete with NPI, NABP, DEA, corporation ID numbers and ALL major third party contracts! — All essential for establishing...

$175,000
Details
High Volume Texas Pharmacy Opportunity
Texas

Overview: Take advantage of this rare opportunity to acquire two established pharmacies located in the heart of West Texas, each boasting over 40 years of successful operation. With combined sales exceeding $8.1 M and generating over $1.4M in GP, this thriving business is well-positioned for continued...

$997,000
Cash Flow: $350,000
Details
Profitable Texas Pharmacy with Seller Financing
Texas

Established Profitable East Texas Pharmacy with DME & Oxygen Component! ***Seller Financing Available*** Asking Price: Negotiable Inventory: $120,000 Gross Profit: 38% Sales: $1.66 Million Annual Scripts: 35K Seller's Discretionary Earnings (SDE): $400,000+ EBITDA: $250,000 Reason for Selling:...

$500,000
Cash Flow: $250,000
Details
Established Pharmacy for Sale in Texas
Bexar County, TX

LISTING ID # 37089 Take a close look at this well established pharmacy located in an affluent neighborhood. This pharmacy has been in business for 20 years with the current owner who seeks to retire. There is a PIC in place currently who will stay on with a new owner in this capacity or as a staff...

$450,000
Cash Flow: $140,152
Details
Trusted Neighborhood Pharmacy in Harris County Tex
Harris County, TX

LISTING ID # 37246 All Pharmacists – Quaint, Trusted Neighborhood Pharmacy. Are you a licensed pharmacist ready to step out from under the corporate umbrella and truly make a difference in your community? This is your chance to own a neat, well-kept, and deeply rooted independent pharmacy serving...

$750,000
Cash Flow: $170,000
Details
Houston Area Retail Pharmacy $200k
Houston, TX

Houston Area Retail Pharmacy $200k Turn key retail pharmacy that has been in business for about 3 years. The pharmacy is currently filling an average of 35-40 scripts per day. The pharmacy has all major PBM’s and is in good standing with all the licenses. This is lease space of about 1200 Sq....

On Request
Details
Pharmacy for Sale in Texas
Dallas County, TX

LISTING ID # 37176 Pharmacy is a well-established, community-focused independent pharmacy located in Dallas, Texas. Founded in 2006 and owned by the current pharmacist-in-charge since 2013, this pharmacy has built a loyal base of patients and referral relationships over more than 13 years of continuous...

$475,000
Cash Flow: $78,434
Details
Harris County, TX

URAC-Accredited Mail Order Pharmacy represents a strategic acquisition opportunity in the pharmaceutical services sector. This fully operational Class A Community Pharmacy maintains active licensure through 2027 with no disciplinary history and operates as a corporation with comprehensive regulatory...

On Request
Details
Pharmacy with Strong Growth Potential
Fort Bend County, TX

LISTING ID # 37302 This neighborhood pharmacy is ready for its next owner as the current seller prepares for retirement. Located in a small, close-knit community, the pharmacy offers a warm, local feel and a loyal customer base. The seller currently operates the business full-time and is willing...

$70,000
Cash Flow: $20,000
Details
Thriving Rural Pharmacy Near Dallas-Fort Worth
Dallas, TX

Charming Small Town within 1 ½ Hours of DFW Metroplex, Rural Dallas Area Join the ranks of successful health care entrepreneurs with this lucrative Pharmacy opportunity nestled in a quaint small town in the rule Dallas area with the solid track record of over 3.6 million in total revenue and filling...

On Request
Details
Round Rock, TX

Be your own boss, own a vending company already set in premium locations. Convenience at your fingertips Business is an automated retail system offering instant, self-serve over-the-counter and personal care pharmaceutical products in high-traffic but traditionally underserved areas, accessible 24...

On Request
Details
Austin, TX

A rare opportunity to acquire a highly respected, multi-location pharmacy operation with a diverse revenue stream and deep community roots in a major Texas city. This family-owned enterprise has successfully evolved beyond traditional pharmacy services to create multiple profit centers while maintaining...

On Request
Details
Mail Order Pharmacies in the Houston Market
Houston, TX

Three mail-order pharmacies are available for sale in the thriving Houston market. These pharmacies are licensed in 18 states and come with established mail-order contracts with major Pharmacy Benefit Managers (PBMs). They hold accreditations through URAC, VIPPS, and ACHC. Two of these pharmacies do...

On Request
Details
Rural Texas Pharmacy near San Antonio and Houston
Texas

Rural Texas near San Antonio and Houston. Only pharmacy in town. Filling 40,000 scripts per year and $2.7M in total revenue. Very consistent numbers over last 3 years.

On Request
Details
Houston Retail Pharmacy
Houston, TX

Local retail Pharmacy for sales North Houston

$150,000
Details
Texas

Pharmacy with compounding equipment with a great location in the Dallas / Fort Woth Region. Profitable with many contracts; Has a reasonable lease. Will need a PIC.

$600,000
Details
Profitable Retail Compounding Pharmacy – All Major Insurance - Greater Houst
Texas

Profitable Retail Compounding Pharmacy – All Major Insurance - Greater Houston, TX Area 10+ Years in Operation | Turnkey Retail Pharmacy with Compounding Capabilities Broker presents a rare opportunity to acquire a fully licensed and profitable retail compounding pharmacy in the fast-growing...

$525,000
Cash Flow: $177,000
Details

Tips for Buying Pharmacies and Drug Stores In Texas

Understand Regulatory and Licensing Requirements

Purchasing a pharmacy in Texas involves compliance with rigorous state and federal regulations. You must understand the rules enforced by the Texas State Board of Pharmacy (TSBP) and the U.S. Drug Enforcement Administration (DEA), including license transfers, background checks, and reporting requirements. Ensure that the existing pharmacy is in good standing with no outstanding compliance issues, as regulatory lapses can derail the transaction or severely impact future operations.

Evaluate Financial Performance and Insurance Contracts

Review the pharmacy’s historical financial statements, focusing on gross revenue, net profit margins, and prescription volume trends. Pay particular attention to contracts with pharmacy benefit managers (PBMs) and major insurers, as these directly affect reimbursement rates and revenue streams. Request detailed information about third-party contracts and analyze whether patients rely heavily on a few key insurance providers. This will help you identify revenue risks and negotiation opportunities going forward.

Assess Location, Staff, and Community Relationships

Location is critical for any retail pharmacy’s long-term success. Evaluate the competition in the area, local demand for pharmacy services, and nearby medical facilities or clinics that can generate foot traffic. Assess the loyalty and competence of existing staff, as experienced and trusted employees are invaluable for a smooth ownership transition. Finally, research the pharmacy’s reputation and relationships within the community; a strong community presence can give you a head start on maintaining and growing the customer base post-acquisition.