Middle-Market Businesses for Sale in the U.S.

Discover top middle-market businesses for sale in the United States on DealStream, the leading online marketplace for established companies. Browse hundreds of vetted listings—spanning manufacturing, services, tech and more—with detailed financials, proven cash flow and growth potential. Whether you’re an aspiring entrepreneur or seasoned investor, our intuitive search filters help you buy middle-market businesses that match your criteria. Start your acquisition journey today and unlock high-value opportunities!

All Matching Deals

NE USA Based Part 135 Charter Business with Fleet
New York, NY

Full/Standard FAA Approval allowing for unlimited aircraft, pilots and aircraft types. This is a "turnkey" cash generating charter machine. Complete with company owned Pilatus PC12s and managed Pilatus PC12, totaling 4 aircraft managed. Comes complete with training program, pilot teams, DO/DM/CP...

$13,500,000
Cash Flow: $3,000,000
Details
Texas Specialty Pharmacy Operation - two locations
Texas

Well run pharmacies with a full staff (including pharmacists, technicians, and customer service reps) who would stay on post transaction. Pharmacies are currently absentee run, making this the perfect opportunity for a buyer looking to add a pharmacy to their portfolio. Seller is looking for a buyer...

$5,850,000
Cash Flow: $2,372,429
Details
Highly Profitable Texas Pharmacy
Texas

High volume and very profitable pharmacy specializing in specific disease states. This pharmacy has been in business for over five years with continued growth. All major PBM contracts in place through PSAO. Fully staffed and easily operated by an absentee owner. Direct contracts with many pharma manufactures....

$12,950,000
Cash Flow: $4,892,969
Details
Ohio Pharmacy
Ohio

Very high-volume specialty pharmacy that has been in business for four years with continued growth. All major PBM contracts in place through PSAO. Fully staffed and easily operated by an absentee owner. Direct contracts with many pharma manufactures. Established Prior-Authorization P&P. Pharma voucher...

$5,690,000
Cash Flow: $1,726,793
Details
Illinois Specialty Pharmacy
Illinois

Profitable specialty pharmacy with continued growth. Fully staffed and easily operated by an absentee owner. Direct contracts with many pharma manufacturers. All major PBM contracts in place through PSAO. Established Prior-Authorization P&P. Pharma voucher program contracts are also in place. Annual...

$8,500,000
Cash Flow: $2,319,244
Details
Travel & Mobile Accessories Brand / $40M+ in sales
Florida

This is a rare opportunity to acquire a profitable, IP-rich consumer lifestyle brand operating at the lucrative intersection of the $9.9T travel industry and the high-demand mobile accessory sector. With over $40 million in lifetime revenue, numerous patents for their product designs, and high-profile...

$10,646,522
Cash Flow: $4,982,024
Details
New York

Highly Profitable, Long-Established Plumbing & Heating Contractor – Nassau/Suffolk, NY A rare opportunity to acquire a 67-year-old plumbing, heating, and remodeling contractor serving Nassau and Suffolk counties. This business operates from a strategically located 4,500 sq. ft. facility in Nassau...

$5,200,000
Cash Flow: $1,300,000
Details
Full-service Accounting/Tax preparation Business
Miami, FL

Full-Service Accounting, Tax Preparation, and Insurance Business – Miami-Dade County This well-established firm offers comprehensive accounting, tax preparation, and property & casualty insurance services. The company provides a wide range of offerings, including: Personal and corporate tax return...

$9,000,000
Cash Flow: $2,560,343
Details
Profitable NY/NYC MBE-Certified Remediation Firm
New York, NY

Profitable NY/NYC MBE-Certified Environmental & Demolition Contractor – $10M+ Revenue, Strong Backlog, Blue-Chip Clients. Established New York–based environmental remediation and specialty contracting firm with over 13 years of proven performance, holding Minority Business Enterprise (MBE) certification...

$6,100,000
Cash Flow: $1,800,000
Details
Nationwide B2B Pharmacy Tech Marketplace
United States

High-Margin, Nationwide B2B Pharmacy Tech Marketplace (Asset-Light, Rapid Growth). A fast-growing B2B online marketplace in the regulated healthcare space is now available for confidential acquisition. The platform connects licensed buyers and sellers nationwide, offering an easy-to-use, compliance-oriented...

$12,000,000
Cash Flow: $2,300,000
Details
Alaska

Home Care agency Based in Alaska Providing Non Skilled Home Care Payer sources- LTC, Private Pay, VA

$6,000,000
Cash Flow: $1,500,000
Details
Luxury Concrete Design Construction Co.
Scottsdale, AZ

Renowned, respected, 50-year Concrete Finishing business located in Scottsdale, Arizona. Founded in 1974, this company has built a high-quality long-standing reputation for concrete design and finishing, within the Golf Course and Resorts sector. The business has long-standing repeat clients, offering...

$6,000,000
Cash Flow: $1,101,352
Details
New York, NY

Confidential sale of a Premier Independent, long‑established, NYC‑based roll‑off and carting company serving the NYC metro area. This asset‑heavy, platform provides dumpster, debris removal and recycling services to New York’s most prominent general contractors and key city agencies. The business is...

$7,950,000
Cash Flow: $1,250,000
Details
Tobacco Manufacturing Factory
Greenville, NC

Fully operating, Large 80,000 sq ft building with offices, factory production floor, warehouse, loading docks in the heart of NC tobacco country on approx 10 acres of land. Multiple high speed tobacco product lines capable of making and packing cigarettes, little cigars, cigarillos etc. appraised...

$9,500,000
Details
Fast Growing PK-6th with Real Estate
United States

This innovative Preschool and Elementary was established in 2022 with the purchase of a 37,000 SF building on 1.5 acres. The building was completely renovated and has the capacity for up to 444 students. The campus features large, bright classrooms, an Indoor playground and a courtyard playground...

$7,499,000
Details
Profitable Montessori Schools with Real Estate
United States

*This esteemed Montessori School has been catering to young students for more than 6 decades. *The sale includes real property with beautiful grounds in excess of 2.5 acres plus multiple buildings. *Three campuses (1 owned and 2 leased) that provide an ideal learning environment. *Enrollment of...

$6,999,999
Details
Profitable Montessori Schools with Real Estate
United States

Prestigious Montessori educational facility with three campuses. Located on the east coast for over six decades, this institution has been synonymous with excellence in Montessori education. Situated in a prime location, this educational facility boasts state-of-the-art Montessori classrooms plus 2.5...

$6,999,999
Details
Midwest Construction Equipment Rental Business
Illinois

This well-established equipment rental company has built a strong reputation over multiple generations as a trusted provider for both residential and commercial markets. Originally founded as a local retail operation, the business successfully transitioned into tool and equipment rentals, leading to...

$5,036,245
Cash Flow: $638,951
Details
Luxury Home Builder and Developer
Scottsdale, AZ

Founded in 2001 with numerous awards, accolades, magazine articles, and news coverage, Luxury Home Builder and Developer is the one of the top luxury homebuilders in Scottsdale, successfully completing over 500 custom home and development projects, totaling over $1billion in value and counting. These...

$20,000,000
Cash Flow: $5,735,064
Details
Florida Retail Pharmacy
Florida

This pharmacy has strong community ties and is located in the prime location with quick access to all major local highways. Clean books, licenses and contracts. The pharmacy has an overwhelmingly positive reputation among physicians and patients alike. The pharmacy is equip with top of the line software...

$14,900,000
Cash Flow: $3,975,495
Details
Established Cutting-Edge Software, R&D, & Digital
Boulder, CO

Business is a cutting edge telecommunications, data science, and internet infrastructure lab that also provides technology staffing services and consultants. We have architects, developers, and analysts on 3 continents with clients and production operations in over 100 countries and 35 supported...

$6,600,000
Cash Flow: $600,000
Details
Boston, MA

The communications protocol that is the underpinning of the Internet was designed with two vital defects. 1. An unpreventable and inevitable bottleneck. 2. A whack-a-mole security defect. For this reason, fortune 1,000 companies have been driven to invest in more secure private networks (MPLS)....

$10,000,000
Details
Profitable, Vertically-Licensed NY Cannabis Co.
New York

This is a confidential offering to acquire a premier, next-generation cannabis CPG and cultivation company already dominating the New York market. With over $6M in sales since April 2023 , placement in 85+ NY dispensaries , and a full suite of cultivation, processing, and distribution licenses, this...

$10,500,000
Cash Flow: $690,000
Details
Well-established Specialty Pharmacy For Sale
Florida

Founded in 2004, this pharmacy has built a strong reputation and a loyal customer base. With contracts with all major insurance carriers and a 340B license, this business offers a seamless transition for an experienced operator or investor looking to enter or expand within the specialty pharmacy sector. The...

$14,999,999
Cash Flow: $2,500,000
Details
Branded Hair Loss Ecommerce Treatment Products
Miami, FL

The Company operates as a consumer retail business focused on providing hair concealment and haircare solutions through a combination of e-commerce and marketplace channels. It manages a lean in-house team primarily for fulfillment while outsourcing key marketing and digital functions to agencies. Manufacturing...

$16,000,000
Cash Flow: $2,000,000
Details

Tips for Buying A Middle-Market Business In US

Understand the Market and Prepare Thoroughly

Before making any moves, invest time in market research specific to your industry of interest and the broader economic climate. Middle-market businesses often have more complex structures, customer bases, and operational challenges compared to smaller firms. Familiarize yourself with recent trends, valuation multiples, and competitive dynamics. Assemble a team of experienced advisors—including a business broker, attorney, and accountant—who specialize in middle-market transactions. Being well-prepared gives you confidence during negotiations and helps you avoid potential pitfalls.

Conduct Rigorous Due Diligence

Due diligence is crucial to uncover the true health and risk profile of any target business. Go beyond surface-level financial evaluations by digging into tax records, employee contracts, supplier agreements, customer relationships, and any legal or regulatory issues. Review the company’s operations, analyzing its strengths, weaknesses, and reliance on key individuals. Ask for detailed explanations of any unusual transactions or inconsistencies. A meticulous due diligence process helps you validate the business’s value and flag any deal-breakers before you proceed.

Plan for Integration and Post-Sale Success

Buying a middle-market business isn’t just about closing the deal—it’s about what happens afterward. Start preparing your post-acquisition integration strategy early, focusing on retaining key employees, maintaining customer relationships, and ensuring business continuity. Develop a clear communication plan for internal and external stakeholders. Outline your growth and operational improvement initiatives. By planning your integration in advance, you maximize your chances of a smooth transition and long-term success with your new business.