Explore Businesses for Sale in San Diego County

Discover the most comprehensive selection of San Diego County businesses for sale on DealStream, your premier online marketplace for buying and selling profitable ventures in Southern California. From turnkey restaurants and thriving e-commerce stores to established service companies and franchise opportunities, our up-to-date listings feature detailed financials, owner insights, and broker support—everything you need to confidently buy a business in San Diego County. Browse now to seize your next great investment in one of California’s fastest-growing markets!

All Matching Deals

Relocatable San Diego Hospice
San Diego, CA

ACHC-accredited hospice agency licensed in California and approved to operate within San Diego County GSA*. The business is organized as a California C-Corporation and holds an active hospice license valid through October 11, 2027*. This opportunity offers a compliant platform for a qualified buyer...

$600,000
Details
San Diego Medicare Home Health for Sale
San Diego, CA

This opportunity represents the acquisition of a well-established Medicare-certified home health agency operating in San Diego County, California. The business is structured as a California Subchapter S-Corporation and has been in continuous operation since 2017, serving the local medical community...

$800,000
Details
Oceanside Hospice For Sale
Oceanside, CA

This is a rare opportunity to acquire a clean, accredited hospice agency licensed in California and based in Southern California. The business operates under a California C-Corporation and is currently on a month-to-month lease at just $545/month, with approximately 800 sq. ft. of office space. The...

$600,000
Details
Independent Music Equipment E-Com Store HQ
San Diego, CA

The Company is a well-established musical instrument retailer with a strong national reputation among manufacturers, dealers, and customers. It is a well-run, respected operation known for authenticity, specialized product knowledge, and exceptional customer service. Founded in the early 2000’s as a...

$2,600,000
Cash Flow: $870,014
Details
World-Class Restoration & Sales Of Luxury Cars
San Diego, CA

**NOTE TO BUYERS: Buyers need to have at least $2.5 M available. There is no financing available. This is a lifestyle business. Established in 1989, the business is a premier restoration, sales, consignment, and service facility specializing in rare and investment-grade classic automobiles, with...

On Request
Details
San Diego, CA

This digital agency has been growing rapidly over the last 5 years, launched its first monetized SaaS product in 2023 and is looking for a growth partner to help take advantage of on-the-horizon opportunities. The Company primarily serves ecommerce clients. The firm competes primarily on operations,...

$1,750,000
Cash Flow: $430,000
Details
San Diego, CA

This business was founded by a software engineer with 44 years of experience in Cable TV Billing, Subscriber Management, and Provisioning systems, developed a fully scalable Cable TV Billing/Authorization System. This software, licensed by companies such as Motorola Broadband and Shaw Communications,...

$250,000
Cash Flow: $1,429
Details
Profitable SD Commercial Janitorial Service Franch
San Diego, CA

This robust commercial janitorial services company, located in San Diego, generates revenue through recurring janitorial contracts for commercial properties, providing services such as daily janitorial tasks, day porter services, one-time cleanups, construction cleanups, floor care, and supply services....

$350,000
Cash Flow: $136,000
Details
Turnkey Aesthetics & Anti-Aging Practice
San Diego, CA

This thriving, physician-founded aesthetics and anti-aging practice operates on a unique, cash-only model that blends advanced aesthetic services with functional and preventive medicine. Since opening in 2018, the clinic has grown organically to generate over $2.2 million in annual revenue by 2022—without...

$990,000
Cash Flow: $408,260
Details
Sold - Inland North San Diego
San Diego County, CA

Practice Fact Sheet: Inland North San Diego County Total Gross Income: $300,000 Net Profit: $200,000 with Owner add backs Purchase Price: $345,000 – Financing available to qualified applicants. Various programs available. Call for details. Year Established: 1988 Accounting, bookkeeping,...

$345,000
Cash Flow: $200,000
Details
San Diego Optometry Practice Grossing almost $700K
San Diego County, CA

Great optometry practice with excellent net profit. Established over 40 years, this office boasts a strong adjusted net (before doctor wages) of almost $200,000 in 2022 on sales of $665,000. Revenue has been stable through the years. The office is 1,500 sq ft and includes 2 exam rooms, contact lens...

On Request
Details
Celeb-Favorite Skincare Brand: Remote, Scalable
San Diego, CA

***Currently Under Contract- Full Price, ALL CASH Profitable Skincare Brand loved by celebrities, protected by global trademarks This high-margin, press-featured skincare brand has cult status and untapped growth levers. Products are stocked by leading retailers like Dermstore, CultBeauty and...

$2,650,000
Cash Flow: $664,972
Details
Optometry Office San Diego Over $1.3 Million Gross
San Diego County, CA

OPTOMETRY PRACTICE FOR SALE: San Diego, Ca San Diego Over $1.3 million gross, 2 location Optometry office. Great investment and even better opportunity for first time buyer. Grossing just over $1.3 million combined from two locations, these offices show very strong adjusted owner benefit of...

On Request
Details
Fresh Superfood Bowls and Smoothies Franchise
San Diego County, CA

Price Reduced! This thriving superfood café offers a menu packed with allergy-friendly options, carefully prepared to avoid cross-contact with common allergens. Signature açaí bowls are crafted with no ice, artificial preservatives, frozen yogurt, trans fats, or fillers — just pure, nutrient-dense ingredients,...

$125,000
Cash Flow: $58,000
Details
Chiropractic Practice for Sale in San Diego, CA
San Diego, CA

This 24-year-established chiropractic practice in San Diego offers an enviable lifestyle with high disposable income. With a trained associate in place and highly transferable techniques, this clinic ensures smooth operations and minimal attrition. The practice enjoys abundant new patients, over 300...

On Request
Cash Flow: $298,000
Details
San Diego, CA

Ideally located in the heart of San Diego, this high-performing dental practice benefits from excellent access, visibility, and a dense urban patient base. The practice has averaged over eighty (80) new patients per month over the past three years and features eleven operatories, creating a strong foundation...

On Request
Details
Premier Anti-Aging & Regenerative Medicine Clinic
San Diego, CA

Profitable Regenerative Medicine Clinic Scalable Model Founded by a nationally recognized pioneer in Anti-Aging and Regenerative Medicine, this cash practice has been helping patients since 1996. It has served individuals in California and from nearly every continent, focusing on optimizing health,...

$495,000
Cash Flow: $369,962
Details
San Diego CA Chiropractic Practice for Sale
San Diego, CA

San Diego CA Chiropractic Practice for Sale San Diego chiropractic clinic with steady new-patient flow and proven systems for a smooth transition. Strong referral network, AR available for immediate cash flow, and passive income from other providers support consistent performance. Modern, inviting...

On Request
Details
Established Strength & Conditioning Fitness Studio
San Diego County, CA

Own a boutique fitness studio in one of San Diego’s most desirable and high-traffic neighborhoods. This established studio offers a results-driven training model that combines progressive strength and conditioning, expert coaching, and technology supported programming, designed for all fitness levels....

$300,000
Details
San Diego Chiropractic Practice for Sale
San Diego, CA

Sunny San Diego Practice Now Available! Well-established, diversified practice with loyal client base, located in one of the best climates in the US is available for sale NOW! Motivated seller will stay on for smooth transition and training if necessary. Working just 3-1/2 days per week and taking...

On Request
Details
San Diego, CA

This business is the premiere real estate publication in a popular Mexico destination. When the publication launched, it quickly established itself as THE recognized publication and today publishes three well recognized issues per year. Listings and a digital magazine are also posted to their website...

$500,000
Cash Flow: $134,104
Details
San Diego, CA

NEW Turnkey Startup Website Business. The website comes programmed with products and suppliers to drop ship the products for you. No programming skills or experience is required to profit from this highly lucrative industry.There is no inventory to carry and nothing to ship. You can own and operate...

$799
Details
San Diego CTY CA Chiropractic Practice for Sale
San Diego, CA

High net profit, CASH practice in sunny San Diego County! A well-established, cash practice with average annual collections of over $240,000 – average net profit of $180,000 for the past four years - with NO ADVERTISING! 59 pv/wk and 10 np/mo with two weeks’ vacation! Practice is located on the first...

On Request
Details
San Diego, CA

CABH1R - $1 Million Revenue Outpatient Mental Health Clinic Based in the San Diego, California Area Company Overview Broker is pleased to exclusively introduce an outpatient mental health clinic for sale in the coastal San Diego, California area. This well-established clinic provides in office and...

On Request
Details
Franchised Printing Business
San Diego, CA

San Diego's go-to franchised printer offering a full range of services with fast turnaround, creative designs, full color printing and graphic design plus copying. The business uses the latest printing and document management technology, they handle projects from start to finish. The experienced staff...

$195,000
Cash Flow: $120,000
Details

Tips for Buying A Business In San Diego County, CA

Understand the Local Market Dynamics

San Diego County is a diverse market with industries ranging from tourism and hospitality to biotech and defense. Before making any commitments, take the time to research the local business landscape thoroughly. Analyze recent sales, current industry trends, population demographics, and economic forecasts specifically for San Diego. By understanding what drives business in the region, you’ll be in a much stronger position to identify high-potential opportunities and avoid sectors that may be oversaturated or facing headwinds.

Conduct Thorough Due Diligence

Due diligence is critical no matter where you buy, but in San Diego there are additional local considerations, such as zoning laws, environmental regulations, and coastal commission guidelines. Carefully review financial statements, tax returns, and operational data for at least the last three years. Don’t overlook potential hidden liabilities, such as outstanding permits or wage disputes, which can be more common in popular hospitality-focused areas. Consider hiring local experts—CPAs, attorneys, and business brokers—familiar with San Diego’s regulatory environment to help you identify any red flags.

Leverage Local Resources and Networks

San Diego has a vibrant community of business owners and support organizations, including the San Diego Regional Chamber of Commerce, local Small Business Development Centers, and industry-specific associations. Engage with these networks to gain insights, mentorship, and even insider leads on businesses coming to market. Networking locally can introduce you to reputable vendors and help you build relationships that are crucial for a smooth transition and long-term success after the purchase. These resources can also connect you to information about local grant programs or incentives that may make your acquisition more attractive.