San Diego Businesses for Sale – Discover Your Perfect Acquisition
Discover the best San Diego businesses for sale on DealStream—the premier online marketplace connecting buyers and sellers across Southern California. Whether you’re hunting for a profitable restaurant, retail shop, tech startup or service company, our comprehensive listings of businesses for sale in San Diego make it easy to find the perfect opportunity. Start browsing today to access exclusive deals, detailed financials, and direct seller connections—and take the first step toward owning your dream business in America’s most vibrant coastal market.
Showcased Deals
Relocatable San Diego Hospice
ACHC-accredited hospice agency licensed in California and approved to operate within San Diego County GSA*. The business is organized as a California C-Corporation and holds an active hospice license valid through October 11, 2027*. This opportunity offers a compliant platform for a qualified buyer...
World-Class Restoration & Sales Of Luxury Cars
**NOTE TO BUYERS: Buyers need to have at least $2.5 M available. There is no financing available. This is a lifestyle business. Established in 1989, the business is a premier restoration, sales, consignment, and service facility specializing in rare and investment-grade classic automobiles, with...
Growing Ecommerce Optimization and Support Agency
This digital agency has been growing rapidly over the last 5 years, launched its first monetized SaaS product in 2023 and is looking for a growth partner to help take advantage of on-the-horizon opportunities. The Company primarily serves ecommerce clients. The firm competes primarily on operations,...
All Matching Deals
Relocatable San Diego Hospice
ACHC-accredited hospice agency licensed in California and approved to operate within San Diego County GSA*. The business is organized as a California C-Corporation and holds an active hospice license valid through October 11, 2027*. This opportunity offers a compliant platform for a qualified buyer...
San Diego Medicare Home Health for Sale
This opportunity represents the acquisition of a well-established Medicare-certified home health agency operating in San Diego County, California. The business is structured as a California Subchapter S-Corporation and has been in continuous operation since 2017, serving the local medical community...
Independent Music Equipment E-Com Store HQ
The Company is a well-established musical instrument retailer with a strong national reputation among manufacturers, dealers, and customers. It is a well-run, respected operation known for authenticity, specialized product knowledge, and exceptional customer service. Founded in the early 2000’s as a...
World-Class Restoration & Sales Of Luxury Cars
**NOTE TO BUYERS: Buyers need to have at least $2.5 M available. There is no financing available. This is a lifestyle business. Established in 1989, the business is a premier restoration, sales, consignment, and service facility specializing in rare and investment-grade classic automobiles, with...
Growing Ecommerce Optimization and Support Agency
This digital agency has been growing rapidly over the last 5 years, launched its first monetized SaaS product in 2023 and is looking for a growth partner to help take advantage of on-the-horizon opportunities. The Company primarily serves ecommerce clients. The firm competes primarily on operations,...
Cable TV Billing & Authorization Software for Sale
This business was founded by a software engineer with 44 years of experience in Cable TV Billing, Subscriber Management, and Provisioning systems, developed a fully scalable Cable TV Billing/Authorization System. This software, licensed by companies such as Motorola Broadband and Shaw Communications,...
Profitable SD Commercial Janitorial Service Franch
This robust commercial janitorial services company, located in San Diego, generates revenue through recurring janitorial contracts for commercial properties, providing services such as daily janitorial tasks, day porter services, one-time cleanups, construction cleanups, floor care, and supply services....
Turnkey Aesthetics & Anti-Aging Practice
This thriving, physician-founded aesthetics and anti-aging practice operates on a unique, cash-only model that blends advanced aesthetic services with functional and preventive medicine. Since opening in 2018, the clinic has grown organically to generate over $2.2 million in annual revenue by 2022—without...
Celeb-Favorite Skincare Brand: Remote, Scalable
***Currently Under Contract- Full Price, ALL CASH Profitable Skincare Brand loved by celebrities, protected by global trademarks This high-margin, press-featured skincare brand has cult status and untapped growth levers. Products are stocked by leading retailers like Dermstore, CultBeauty and...
Chiropractic Practice for Sale in San Diego, CA
This 24-year-established chiropractic practice in San Diego offers an enviable lifestyle with high disposable income. With a trained associate in place and highly transferable techniques, this clinic ensures smooth operations and minimal attrition. The practice enjoys abundant new patients, over 300...
San Diego General Dentistry Practice For Sale
Ideally located in the heart of San Diego, this high-performing dental practice benefits from excellent access, visibility, and a dense urban patient base. The practice has averaged over eighty (80) new patients per month over the past three years and features eleven operatories, creating a strong foundation...
Premier Anti-Aging & Regenerative Medicine Clinic
Profitable Regenerative Medicine Clinic Scalable Model Founded by a nationally recognized pioneer in Anti-Aging and Regenerative Medicine, this cash practice has been helping patients since 1996. It has served individuals in California and from nearly every continent, focusing on optimizing health,...
San Diego CA Chiropractic Practice for Sale
San Diego CA Chiropractic Practice for Sale San Diego chiropractic clinic with steady new-patient flow and proven systems for a smooth transition. Strong referral network, AR available for immediate cash flow, and passive income from other providers support consistent performance. Modern, inviting...
San Diego Chiropractic Practice for Sale
Sunny San Diego Practice Now Available! Well-established, diversified practice with loyal client base, located in one of the best climates in the US is available for sale NOW! Motivated seller will stay on for smooth transition and training if necessary. Working just 3-1/2 days per week and taking...
Leading Real Estate Publication for Popular Mexico
This business is the premiere real estate publication in a popular Mexico destination. When the publication launched, it quickly established itself as THE recognized publication and today publishes three well recognized issues per year. Listings and a digital magazine are also posted to their website...
Global Baby Clothes Dropship Website Business
NEW Turnkey Startup Website Business. The website comes programmed with products and suppliers to drop ship the products for you. No programming skills or experience is required to profit from this highly lucrative industry.There is no inventory to carry and nothing to ship. You can own and operate...
San Diego CTY CA Chiropractic Practice for Sale
High net profit, CASH practice in sunny San Diego County! A well-established, cash practice with average annual collections of over $240,000 – average net profit of $180,000 for the past four years - with NO ADVERTISING! 59 pv/wk and 10 np/mo with two weeks’ vacation! Practice is located on the first...
$1M Rev Outpatient Mental Health Clinic, SD CA
CABH1R - $1 Million Revenue Outpatient Mental Health Clinic Based in the San Diego, California Area Company Overview Broker is pleased to exclusively introduce an outpatient mental health clinic for sale in the coastal San Diego, California area. This well-established clinic provides in office and...
Franchised Printing Business
San Diego's go-to franchised printer offering a full range of services with fast turnaround, creative designs, full color printing and graphic design plus copying. The business uses the latest printing and document management technology, they handle projects from start to finish. The experienced staff...
Outpatient Mental Health Clinic, CA $1m Revenue
Company Overview Broker is pleased to introduce an outpatient mental health clinic for sale in the coastal San Diego, California area. This well-established clinic provides in office and telehealth services to people of all ages, including children, adolescents, adults, college students, and families....
San Diego Clinical Lab, 2.4M Gross, 1M Net
Broker is pleased to present the opportunity to acquire a profitable, full-service high-complexity clinical laboratory located in San Diego, California. • Established: 2019 • Specialties: Pharmacogenomics (PGx), Molecular Diagnostics with MolDx Z Code (Mental Health, Pain Management, Cardiovascular),...
Profitable Luxury Home Development Co.
Established luxury home development and design-build company serving San Diego's most affluent areas. Founded in 1998 averaging $3.5 million in revenue and $350,000 SDE. Premium projects ranging from $500k-$2M+ and $3.2M in contracted work scheduled for 2026.
General Auto Repair - Long Established
General auto repair, transmission and suspension service. Increasing revenue and profits year after year. In business for 43 years, with a long, consistent history of profitability. This business has a great reputation in the community with five star Yelp/Google rating. A+ BBB rating. 6,000 sq ft with...
2-Location [CA & CO] Med Spa For Sale
This $3,000,000 EBITDA, 2-location practice is led by a powerhouse aesthetic industry visionary who has cultivated a team of high performing aesthetic providers. The sellerʼs intentional leadership style has developed multiple thriving injectors, with continued opportunity for growth within the existing...
La Jolla/San Diego, CA Practice for
Established successful Naturopathic Practice collecting $202,892.00. I'm looking for the right dedicated person to take over the practice so I can focus on my family. My main demographics are women between 18 & 45 ~ supporting digestive health, hormone health and preconception/fertility issues. Strong...
Tips for Buying A Business In San Diego, CA
Understand the Local Market
San Diego offers a unique business landscape influenced by its vibrant tourism sector, military presence, and growing tech industry. Before you make any purchase, thoroughly research industry trends, customer demographics, and local competition. Connect with local business associations, review San Diego’s economic reports, and use tools like BizBuySell or the San Diego Regional Chamber of Commerce to gain deeper insights. A clear understanding of why businesses succeed or fail in your chosen area will help you make a well-informed decision.
Conduct Thorough Due Diligence
Due diligence is critical for uncovering the true value and potential risks of any business. In San Diego, pay particular attention to seasonality (impacted by tourism), lease agreements (especially in popular neighborhoods), permitting requirements, and potential environmental regulations. Work with a local CPA and legal advisor to review financial statements, tax records, and any existing contracts. Make sure you understand any city or state-level regulations unique to Southern California, such as specific labor laws and health regulations.
Leverage Local Resources and Advisors
As a buyer, you’ll greatly benefit from working with professionals who understand the San Diego business environment. Engage with experienced local brokers, attorneys, and CPAs who can guide you through the buying process, mitigate risks, and spot hidden opportunities. Consider networking with the San Diego Small Business Development Center (SBDC) or joining entrepreneur groups to get peer advice and support. Surrounding yourself with knowledgeable advisors and leveraging San Diego’s business support network will increase your likelihood of a successful acquisition.
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